Ethanol → HCID 68591454, compound

HRID 2116684Notes

Reaction equation

HRID 2116684 reaction equation
[NH2:1][C@H:2]([CH2:6][C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[C:10]([NH2:17])=[C:9]([Cl:18])[CH:8]=1)[C:3]([OH:5])=[O:4].[CH3:19][CH2:20]O>Cl>[NH2:1][C@H:2]([CH2:6][C:7]1[CH:12]=[C:11]([C:13]([F:15])([F:16])[F:14])[C:10]([NH2:17])=[C:9]([Cl:18])[CH:8]=1)[C:3]([O:5][CH2:19][CH3:20])=[O:4]

Participants

4

Reactant 2

HCID 702EthanolHCID 68590975HCID 68590975, compound

Product 1

HCID 68591454HCID 68591454, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 3.5 g (10.97 mmol) (R)-2-amino-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-propionic acid in 100 mL EtOH and 70 mL ethanolic hydrochloric acid solution (11.5 M) was stirred overnight at RT. The mixture was evaporated down i. vac., the residue was taken up in 150 mL water, combined with 30 mL 15% K2CO3 solution, extracted with 150 mL EtOAc, the organic phase was separated off and dried over Na2SO4. After the desiccant and solvent had been eliminated the desired product was obtained.

Workup

  1. customThe mixture was evaporated down i
  2. extractionextracted with 150 mL EtOAc
  3. customthe organic phase was separated off
  4. dry with materialdried over Na2SO4
  5. customwas obtained

Sources & evidence

ORD record
ord-be87910d35164a0a8814a401f311c77e
Source dataset
uspto-grants-2008_10
Patent number
US07439237B2

Reaction notes

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