Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

A solution of 650 mg of N-(1-BOC-4-piperidinyl-benzylamino)-sulfonyl-3,5-bis-trifluoromethyl-benzamide in 5 ml of CH2Cl2 is treated with 60 ml of 3 N HCl (gas) in diethylether. The mixture obtained is stirred for ca. 12 hours and solvent is evaporated. N-(4-Piperidinyl-benzylamino)-sulfonyl-3,5-bis-trifluoromethyl-benzamide in the form of a hydrochloride is obtained. 1H-NMR (DMSO) δ:1.72-1.86 (m, 4H), 2.90 (m, 2H), 3.20-3.3 (m, 2H), 4.15 (m, 1H), 4.60 (s, 2H, CH2), 7.31 (t, 1H), 7.40 (t, 1H), 7.48 (d, 1H), 8.38 (s, 1H), 8.48 (s, 2H), 8.48 and 8.75 (broad, 2H, NH).

Provenance & Evidence