Hydrochloric Acid → Hydrochloric Acid

HRID 2116752Notes

Reaction equation

HRID 2116752 reaction equation
C([C:8]1([CH:35]=[CH:34][C:33]([N:36]2[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]2)=[CH:32][CH2:31]1)[CH2:9][NH:10][NH:11][C:12](=[O:30])[CH:13]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[C:15]([C:23]([F:26])([F:25])[F:24])[C:14]1=[S:27](=[O:29])=[O:28])(OC(C)(C)C)=O.[ClH:42]>C(Cl)Cl.C(OCC)C>[N:36]1([C:33]2[CH:32]=[CH:31][C:8]([CH2:9][NH:10][NH:11][C:12](=[O:30])[CH:13]3[CH:18]=[C:17]([C:19]([F:21])([F:20])[F:22])[CH:16]=[C:15]([C:23]([F:24])([F:26])[F:25])[C:14]3=[S:27](=[O:29])=[O:28])=[CH:35][CH:34]=2)[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1.[ClH:42]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 86603560HCID 86603560, compound

Product 2

HCID 313Hydrochloric AcidHCID 86603559HCID 86603559, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 650 mg of N-(1-BOC-4-piperidinyl-benzylamino)-sulfonyl-3,5-bis-trifluoromethyl-benzamide in 5 ml of CH2Cl2 is treated with 60 ml of 3 N HCl (gas) in diethylether. The mixture obtained is stirred for ca. 12 hours and solvent is evaporated. N-(4-Piperidinyl-benzylamino)-sulfonyl-3,5-bis-trifluoromethyl-benzamide in the form of a hydrochloride is obtained. 1H-NMR (DMSO) δ:1.72-1.86 (m, 4H), 2.90 (m, 2H), 3.20-3.3 (m, 2H), 4.15 (m, 1H), 4.60 (s, 2H, CH2), 7.31 (t, 1H), 7.40 (t, 1H), 7.48 (d, 1H), 8.38 (s, 1H), 8.48 (s, 2H), 8.48 and 8.75 (broad, 2H, NH).

Workup

  1. customThe mixture obtained
  2. customsolvent is evaporated

Sources & evidence

ORD record
ord-df648726b738442181e7568b73dc1c62
Source dataset
uspto-grants-2008_10
Patent number
US07439362B2

Reaction notes

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