反应详情

温度

10 °C

To 4-(2-pyrrolidon-1-yl)cyclohexylcarboxylic acid are added ethanol (30 mL, 10V/W) and conc. sulfuric acid (0.4 g, 0.2 W/W), and the mixture is heated to reflux for 3.5 hours. After cooling the reaction solution to 10° C., sodium bicarbonate (powder) is thereto added. After foaming is stopped, ethanol is evaporated under reduced pressure. The residue is extracted with ethyl acetate and saturated brine. The resultant solution is dried over magnesium sulfate and evaporated to remove the solvent under reduced pressure to give ethyl 4-(2-pyrrolidon-1-yl)cyclohexylcarboxylate (oil, 2.3 g, 102%).

1. temperaturethe mixture is heated
2. temperatureto reflux for 3.5 hours
3. customethanol is evaporated under reduced pressure
4. extractionThe residue is extracted with ethyl acetate and saturated brine
5. dry with materialThe resultant solution is dried over magnesium sulfate
6. customevaporated
7. customto remove the solvent under reduced pressure