反应详情

温度

100 °C

6.31 ml (0.126 mol) hydrazine hydrate were added drop-wise at ambient temperature to a solution of 35.0 g (0.117 mol) ethyl 2-bromo-3-(but-2-ynyl)-5-formyl-3H-imidazole-4-carboxylate in 400 ml of ethanol. After 30 min stirring 27 ml (0.472 mol) concentrated acetic acid were added and the solution was then stirred for 1 h at 100° C. After cooling the precipitated solid was suction filtered, washed with ethanol and diethyl ether and dried. The solid was further purified by re-crystallization from EtOH.

1. additionwere added
2. temperatureAfter cooling the precipitated solid
3. filtrationfiltered
4. washwashed with ethanol and diethyl ether
5. customdried
6. customThe solid was further purified by re-crystallization from EtOH