Mycophenolic Acid → 37415-62-6

HRID 2116797Notes

Reaction equation

HRID 2116797 reaction equation
[CH3:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH2:10]/[CH:11]=[C:12](/[CH2:14][CH2:15][C:16]([OH:18])=[O:17])\[CH3:13])[C:5]([OH:19])=[C:4]2[C:20]([O:22][CH2:23][C:3]=12)=[O:21].C[O-].[Na+:26]>ClCCl>[CH3:1][C:2]1[C:3]2[CH2:23][O:22][C:20](=[O:21])[C:4]=2[C:5]([OH:19])=[C:6]([CH2:10]/[CH:11]=[C:12](/[CH2:14][CH2:15][C:16]([O-:18])=[O:17])\[CH3:13])[C:7]=1[O:8][CH3:9].[Na+:26]

Participants

4

Reactant 2

HCID 446541Mycophenolic AcidHCID 10942334Sodium Methoxide

Product 1

HCID 2366558437415-62-6

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Mycophenolic acid (3.20 g, 10 mmol) was dissolved in dichloromethane (64 ml). To this solution sodium methoxide (9 mmol, 1.67 ml of its 30% methanolic solution) was added under stirring. The formed suspension was diluted with 256 ml of dichloromethane. After 2 hours stirring at room temperature the solid was filtered off, dried at normal pressure at room temperature. Polymorphism was determined by X-ray diffraction. The obtained material was form M22.

Workup

  1. stirringAfter 2 hours stirring at room temperature the solid
  2. filtrationwas filtered off
  3. customdried at normal pressure at room temperature

Sources & evidence

ORD record
ord-e640e1c6d75e4378a30b5a1cca8dcede
Source dataset
uspto-grants-2008_10
Patent number
US07439373B2

Reaction notes

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