Mycophenolic Acid → MYCOPHENOLATE SODIUM

Participants

Reaction Steps

Mycophenolic acid (3.20 g, 10 mmol) was dissolved in dichloromethane (64 ml). To this solution sodium methoxide (9 mmol, 1.67 ml of its 30% methanolic solution) was added under stirring. The formed suspension was diluted with 256 ml of dichloromethane. After 2 hours stirring at room temperature the solid was filtered off, dried at normal pressure at room temperature. Polymorphism was determined by X-ray diffraction. The obtained material was form M22.

Provenance & Evidence