Hydrochloric Acid → Atomoxetine Hydrochloride

Participants

Reaction Steps

Under stirring, and maintaining temperature between 18° C. and 20° C. by means of water bath cooling, 3.27 g (0.03263 mol) of aqueous hydrogen chloride (36.4%) was dropped on 58.2 g (0.02967 mol) of the atomoxetine base solution obtained above. Atomoxetine hydrochloride then crystallized out. The obtained suspension was stirred at about 20° C. for one hour, the solid is collected by filtration, and washed twice with 6 ml of n-butyl acetate. The solid was collected and dried for 18 hours at 45° C. under vacuum.

Provenance & Evidence