Hydrochloric Acid → Atomoxetine hydrochloride

HRID 2116884Notes

Reaction equation

HRID 2116884 reaction equation
[ClH:1].[CH3:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=1[O:9][C@@H:10]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[CH2:11][CH2:12][NH:13][CH3:14]>>[CH3:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=1[O:9][C@@H:10]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:11][CH2:12][NH:13][CH3:14].[ClH:1]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 54841Atomoxetine

Product 1

HCID 54840Atomoxetine hydrochloride

Procedure

Under stirring, and maintaining temperature between 18° C. and 20° C. by means of water bath cooling, 3.27 g (0.03263 mol) of aqueous hydrogen chloride (36.4%) was dropped on 58.2 g (0.02967 mol) of the atomoxetine base solution obtained above. Atomoxetine hydrochloride then crystallized out. The obtained suspension was stirred at about 20° C. for one hour, the solid is collected by filtration, and washed twice with 6 ml of n-butyl acetate. The solid was collected and dried for 18 hours at 45° C. under vacuum.

Workup

  1. temperaturemaintaining temperature between 18° C. and 20° C. by means of water bath
  2. temperaturecooling
  3. customobtained above
  4. customAtomoxetine hydrochloride then crystallized out
  5. stirringThe obtained suspension was stirred at about 20° C. for one hour
  6. filtrationthe solid is collected by filtration
  7. washwashed twice with 6 ml of n-butyl acetate
  8. customThe solid was collected
  9. customdried for 18 hours at 45° C. under vacuum

Sources & evidence

ORD record
ord-b5f5f8d6c3a742a4bd5b3dbc5d1c308a
Source dataset
uspto-grants-2008_10
Patent number
US07439399B2

Reaction notes

Loading…