Benzil → HCID 11698084, compound

HRID 2116903Notes

Reaction equation

[F:1][C:2]([F:19])([F:18])[C:3]1[C:4]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([NH2:17])=[NH:16])[CH2:11][CH2:10]2)=[N:5][CH:6]=[CH:7][CH:8]=1.[C:20]1([C:26]([C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=O)=O)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[C:20]1([C:26]2[N:16]=[C:15]([N:12]3[CH2:13][CH2:14][N:9]([C:4]4[C:3]([C:2]([F:1])([F:18])[F:19])=[CH:8][CH:7]=[CH:6][N:5]=4)[CH2:10][CH2:11]3)[NH:17][C:28]=2[C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 8651Benzil

HCID 58625863HCID 58625863, compound

Product 1

HCID 11698084HCID 11698084, compound

Procedure

4-(3-(Trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamidine (300 mg, 1.10 mmol, Example 3(a)) reacted with benzil (231 mg, 1.10 mmol, Aldrich) under the conditions of Example 4(b). The crude product was purified by silica gel column chromatography (1:3 EtOAc/hexane) to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 450.

Workup

customThe crude product was purified by silica gel column chromatography (1:3 EtOAc/hexane)

Sources & evidence

ORD record: ord-7f3e260b5593404eb4883198124cb5d9
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07439360B2

Reaction notes

Loading…