Benzil → HCID 11698084, compound

Participants

Reaction Steps

4-(3-(Trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamidine (300 mg, 1.10 mmol, Example 3(a)) reacted with benzil (231 mg, 1.10 mmol, Aldrich) under the conditions of Example 4(b). The crude product was purified by silica gel column chromatography (1:3 EtOAc/hexane) to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 450.

Provenance & Evidence