Trifluoroacetic acid → HCID 178506119, compound

HRID 2116906Notes

Reaction equation

C(O[C:6]([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[NH:15][C:16]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=3)=[C:17]([Cl:19])[N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:30](O)([C:32]([F:35])([F:34])[F:33])=O>>[Cl:19][C:17]1[N:18]=[C:14]([C:11]2[CH2:10][CH2:9][N:8]([C:6]3[C:30]([C:32]([F:35])([F:34])[F:33])=[CH:11][CH:10]=[CH:9][N:8]=3)[CH2:13][CH:12]=2)[NH:15][C:16]=1[C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178451802HCID 178451802, compound

Product 1

HCID 178506119HCID 178506119, compound

Procedure

4-[4-Chloro-5-(4-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester from step (a) above (540 mg, 1.26 mmol) reacted with TFA under the conditions of Example 22(c) to give the title compound as a light-brown oil, which was used directly in the next step without additional purification. MS (ESI, positive ion) m/z: 328 (M+1).

Sources & evidence

ORD record: ord-b0342c2b47684686b02faba38a3a9316
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07439360B2

Reaction notes

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