反应详情

The diazomethylketone derived from Bis-Boc-Tyr (Example 64, 0.750 g, 1.85 mmol) was dissolved in a 1/1 mixture of THF/MeOH (10 mL). A solution of silver benzoate (50 mg) in triethylamine (1 mL) was added. After 15 min of stirring at room temperature the solvent was evaporated and the residue purified by flash chromatography (gradient 10-25% EtOAc/hexane) to yield 749 mg of protected tyrosine methyl ester.

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2. customthe residue purified by flash chromatography (gradient 10-25% EtOAc/hexane)