HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-chlorobenzaldehyde → (+/-)-1-(2-Amino-6-chlorophenyl)-2-(3,4-difluorophenyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-chlorobenzaldehyde | HCID 22399512 | — |
| Reactant | HCID 178505753 | HCID 178505753 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (+/-)-1-(2-Amino-6-chlorophenyl)-2-(3,4-difluorophenyl)ethanol | HCID 69318113 | 57% |
Reaction Steps
This compound was prepared using General Method 1 (EXAMPLE 1) from 2-amino-6-chlorobenzaldehyde (0.30 g, 1.9 mmol) and 3,4-difluorobenzylmagnesium bromide (generated from 3,4-difluorobenzyl bromide and magnesium in ether, 3.9 mmol, 2 equiv) to afford 0.28 g (57%) of (±)-1-(2-amino-6-chlorophenyl)-2-(3,4-difluorophenyl)ethanol after flash chromatography (4:1 hexanes:ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07442696B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-c187a39e288e4920babc609538a053d3 |
| Source note | uspto-grants-2008_10 |