Potassium Carbonate → HCID 178527862, compound

HRID 2117293Notes

Reaction equation

HRID 2117293 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=O.[NH2:15][C:16]([NH2:18])=[S:17].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[CH:4]=[CH:3][N:18]=[C:16]([SH:17])[N:15]=2)=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2723790ThioureaHCID 5375260(E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one

Product 1

HCID 178527862HCID 178527862, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
85 °C

Procedure

To a solution of (2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one (1.5 g, 7.2 mmol) in ethanol (25 ml) was added thiourea (0.60 g, 7.9 mmol) and potassium carbonate (K2CO3) (1.19 g. 8.63 mmol). The resulting suspension was heated to 85° C. for 12 hours then cooled to ambient temperature. The resulting solid was collected and thoroughly washed with water and hexanes to provide a beige solid: EI-MS (m/z) 222 [M+1]+.

Workup

  1. temperaturethen cooled to ambient temperature
  2. customThe resulting solid was collected
  3. washthoroughly washed with water and hexanes
  4. customto provide a beige solid

Sources & evidence

ORD record
ord-871f10f2e2134f7fa1b788730ba2a36d
Source dataset
uspto-grants-2008_10
Patent number
US07442699B2

Reaction notes

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