Hydrochloric Acid → HCID 10087283, compound

HRID 2117396Notes

Reaction equation

HRID 2117396 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:12][CH:13]1[CH2:22][CH2:21][CH2:20][CH2:19][C:14]21OCCO2)=[NH:11].Cl>>[ClH:1].[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[NH:9][C:10]1[NH:11][C:14]2[CH2:19][CH2:20][CH2:21][CH2:22][C:13]=2[N:12]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178512061HCID 178512061, compound

Product 1

HCID 10087283HCID 10087283, compoundYield 157.7%

Procedure

N-(2,6-Dichlorophenyl)-N′-(1,4-dioxaspiro[4.5]dec-6-yl)guanidine (426 mg) was mixed with concentrated HCl (5 ml) and stirred at room temperature for 5 minutes. The resulting precipitate was filtered off and washed with concentrated hydrochloric acid. On dilution of the filtrate with water, a further precipitate separated out and was likewise filtered off. The combined precipitates afforded 311 mg of the desired compound.

Workup

  1. filtrationThe resulting precipitate was filtered off
  2. washwashed with concentrated hydrochloric acid
  3. customOn dilution of the filtrate with water, a further precipitate separated out
  4. filtrationwas likewise filtered off
  5. customThe combined precipitates

Sources & evidence

ORD record
ord-a56ff306414842adaaa83a13ecfc68e3
Source dataset
uspto-grants-2008_10
Patent number
US07442717B2

Reaction notes

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