6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline → (5-Methanesulfonyl-2-morpholin-4-yl-phenyl)-(6-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

HRID 2117406Notes

Reaction equation

HRID 2117406 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2.[CH3:15][S:16]([C:19]1[CH:20]=[CH:21][C:22]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)=[C:23]([CH:27]=1)[C:24](O)=[O:25])(=[O:18])=[O:17]>>[CH3:15][S:16]([C:19]1[CH:20]=[CH:21][C:22]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)=[C:23]([C:24]([N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=3)[CH2:9]2)=[O:25])[CH:27]=1)(=[O:17])=[O:18]

Participants

3

Reactant 2

HCID 181765196-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinolineHCID 211003195-(Methanesulfonyl)-2-(morpholin-4-yl)benzoic acid

Product 1

HCID 11547255(5-Methanesulfonyl-2-morpholin-4-yl-phenyl)-(6-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

Procedure

Prepared in analogy to example 1.1 from 6-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline and 5-methanesulfonyl-2-morpholin-4-yl-benzoic acid (Example 2.4).

Sources & evidence

ORD record
ord-69539b85690c46e18a32c58672b504a7
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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