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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2117406Generated: October 25, 2026

6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline → (5-Methanesulfonyl-2-morpholin-4-yl-phenyl)-(6-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

https://huagongshe.com/reaction/2117406

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinolineHCID 18176519—
Reactant5-(Methanesulfonyl)-2-(morpholin-4-yl)benzoic acidHCID 21100319—
Product(5-Methanesulfonyl-2-morpholin-4-yl-phenyl)-(6-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanoneHCID 11547255—

Reaction Steps

Prepared in analogy to example 1.1 from 6-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline and 5-methanesulfonyl-2-morpholin-4-yl-benzoic acid (Example 2.4).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07442710B2
Source datasetuspto-grants-2008_10
ORD IDord-69539b85690c46e18a32c58672b504a7
Source noteuspto-grants-2008_10