6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline → (4-Methanesulfonyl-biphenyl-2-yl)-(6-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

HRID 2117408Notes

Reaction equation

HRID 2117408 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2.[CH3:15][S:16]([C:19]1[CH:20]=[C:21]([C:31](O)=[O:32])[C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:23][CH:24]=1)(=[O:18])=[O:17]>>[CH3:15][S:16]([C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[C:21]([C:31]([N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=3)[CH2:9]2)=[O:32])[CH:20]=1)(=[O:17])=[O:18]

Participants

3

Reactant 2

HCID 181765196-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinolineHCID 574452544-(methylsulfonyl)-Biphenyl-2-carboxylic acid

Product 1

HCID 11641139(4-Methanesulfonyl-biphenyl-2-yl)-(6-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

Procedure

Prepared in analogy to example 1.1 from 6-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline and 4-methanesulfonyl-biphenyl-2-carboxylic acid (example 2.5).

Sources & evidence

ORD record
ord-d548ac7780284f5998ff1a5699a503fe
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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