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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2117408Generated: October 30, 2026

6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline → (4-Methanesulfonyl-biphenyl-2-yl)-(6-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

https://huagongshe.com/reaction/2117408

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinolineHCID 18176519—
Reactant4-(methylsulfonyl)-Biphenyl-2-carboxylic acidHCID 57445254—
Product(4-Methanesulfonyl-biphenyl-2-yl)-(6-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanoneHCID 11641139—

Reaction Steps

Prepared in analogy to example 1.1 from 6-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline and 4-methanesulfonyl-biphenyl-2-carboxylic acid (example 2.5).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07442710B2
Source datasetuspto-grants-2008_10
ORD IDord-d548ac7780284f5998ff1a5699a503fe
Source noteuspto-grants-2008_10