1,2,3,4-Tetrahydro-7-nitroisoquinoline → (2-Isopropoxy-5-methanesulfonyl-phenyl)-(7-nitro-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

HRID 2117419Notes

Reaction equation

HRID 2117419 reaction equation
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][NH:10][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH:14]([O:17][C:18]1[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][C:19]=1[C:20](O)=[O:21])([CH3:16])[CH3:15]>>[CH:14]([O:17][C:18]1[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][C:19]=1[C:20]([N:10]1[CH2:9][CH2:8][C:7]2[C:12](=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[CH2:11]1)=[O:21])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 64248331,2,3,4-Tetrahydro-7-nitroisoquinolineHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 57445263(2-Isopropoxy-5-methanesulfonyl-phenyl)-(7-nitro-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

Procedure

Prepared in analogy to example 1.1 from 7-nitro-1,2,3,4-tetrahydro-isoquinoline (CA [42923-79-5]) and 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.1).

Sources & evidence

ORD record
ord-6f4749789aec481aa8c9181277906886
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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