5,6,7,8-Tetrahydro-1,3-dioxolo(4,5-g)isoquinoline → (7,8-Dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

HRID 2117441Notes

Reaction equation

HRID 2117441 reaction equation
[O:1]1[C:5]2=[CH:6][C:7]3[CH2:8][CH2:9][NH:10][CH2:11][C:12]=3[CH:13]=[C:4]2[O:3][CH2:2]1.[CH:14]([O:17][C:18]1[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][C:19]=1[C:20](O)=[O:21])([CH3:16])[CH3:15]>>[O:1]1[C:5]2=[CH:6][C:7]3[CH2:8][CH2:9][N:10]([C:20]([C:19]4[CH:23]=[C:24]([S:27]([CH3:30])(=[O:29])=[O:28])[CH:25]=[CH:26][C:18]=4[O:17][CH:14]([CH3:16])[CH3:15])=[O:21])[CH2:11][C:12]=3[CH:13]=[C:4]2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 270135,6,7,8-Tetrahydro-1,3-dioxolo(4,5-g)isoquinolineHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 58677874(7,8-Dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

Procedure

Prepared in analogy to example 1.1 from 5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline (CA [94143-83-6]) and 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.1). MS (m/e): 418.4 (M+H+).

Sources & evidence

ORD record
ord-84179ac5e20b4d4aa872ba91620afa85
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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