6-Chloro-1,2,3,4-tetrahydroisoquinoline → (6-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)-(2-isopropylsulfanyl-5-methanesulfonyl-phenyl)-methanone

HRID 2117448Notes

Reaction equation

HRID 2117448 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6][CH2:5]2.[CH:12]([S:15][C:16]1[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][C:17]=1[C:18](O)=[O:19])([CH3:14])[CH3:13]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([C:18]([C:17]1[CH:21]=[C:22]([S:25]([CH3:28])(=[O:27])=[O:26])[CH:23]=[CH:24][C:16]=1[S:15][CH:12]([CH3:14])[CH3:13])=[O:19])[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 117895946-Chloro-1,2,3,4-tetrahydroisoquinolineHCID 211002522-Isopropylsulfanyl-5-methanesulfonyl-benzoic acid

Product 1

HCID 57445252(6-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)-(2-isopropylsulfanyl-5-methanesulfonyl-phenyl)-methanone

Procedure

Prepared in analogy to example 1.1 from 6-chloro-1,2,3,4-tetrahydro-isoquinoline (CA [33537-99-4]) and 2-isopropylsulfanyl-5-methanesulfonyl-benzoic acid (example 2.7). MS (m/e): 424.1 (M+H+).

Sources & evidence

ORD record
ord-f429033cd07342de91e85e4c76b48b0e
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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