2-Morpholino-5-nitrobenzoic acid → (6-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)-(2-morpholin-4-yl-5-nitro-phenyl)-methanone

HRID 2117449Notes

Reaction equation

HRID 2117449 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6][CH2:5]2.[N:12]1([C:18]2[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][C:19]=2[C:20](O)=[O:21])[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([C:20]([C:19]1[CH:23]=[C:24]([N+:27]([O-:29])=[O:28])[CH:25]=[CH:26][C:18]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)=[O:21])[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 27257552-Morpholino-5-nitrobenzoic acidHCID 117895946-Chloro-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 57445277(6-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)-(2-morpholin-4-yl-5-nitro-phenyl)-methanone

Procedure

Prepared in analogy to example 1.1 from 6-chloro-1,2,3,4-tetrahydro-isoquinoline (CA [33537-99-4]) and 2-morpholin-4-yl-5-nitro-benzoic acid (example 2.8).

Sources & evidence

ORD record
ord-2c44ada27a7b43699fccd3428967c65c
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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