HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine-3-sulfonyl chloride hydrochloride → 5-{3-[(Pyridine-3-sulfonyl)-(4-thiazol-2-yl-benzyl)-amino]-propyl}-thiophene-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine-3-sulfonyl chloride hydrochloride | HCID 12571517 | — |
| Reactant | 5-[3-[(Pyridine-3-sulfonyl)-(4-thiazol-2-yl-benzyl)-amino]-propyl}-thiophene-2-carboxylic acid | HCID 18376062 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 5-{3-[(Pyridine-3-sulfonyl)-(4-thiazol-2-yl-benzyl)-amino]-propyl}-thiophene-2-carboxylic acid methyl ester | HCID 54198026 | — |
Reaction Steps
The title compound of Step B was prepared from 5-[3-(4-thiazol-2-yl-benzylamino)-propyl]-thiophene-2-carboxylic acid methyl ester of Step A and pyridine-3-sulfonyl chloride hydrochloride, of Preparation 2, following the method described in Example 1, Step B using triethylamine in place of N,N-diisopropylethylamine. MS 514 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07442702B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-c08b89b540de46b0bb1ad596e920f225 |
| Source note | uspto-grants-2008_10 |