Pyridine-3-sulfonyl chloride hydrochloride → 5-{3-[(Pyridine-3-sulfonyl)-(4-thiazol-2-yl-benzyl)-amino]-propyl}-thiophene-2-carboxylic acid methyl ester

HRID 2117493Notes

Reaction equation

HRID 2117493 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7]([N:10]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]3[S:30][CH:31]=[CH:32][N:33]=3)=[CH:25][CH:24]=2)[CH2:11][CH2:12][CH2:13][C:14]2[S:18][C:17]([C:19]([OH:21])=[O:20])=[CH:16][CH:15]=2)(=[O:9])=[O:8])[CH:2]=1.Cl.N1C=CC=C(S(Cl)(=O)=O)[CH:36]=1>C(N(CC)CC)C>[CH3:36][O:20][C:19]([C:17]1[S:18][C:14]([CH2:13][CH2:12][CH2:11][N:10]([S:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)(=[O:8])=[O:9])[CH2:22][C:23]2[CH:24]=[CH:25][C:26]([C:29]3[S:30][CH:31]=[CH:32][N:33]=3)=[CH:27][CH:28]=2)=[CH:15][CH:16]=1)=[O:21]

Participants

4

Reactant 2

HCID 12571517Pyridine-3-sulfonyl chloride hydrochlorideHCID 183760625-[3-[(Pyridine-3-sulfonyl)-(4-thiazol-2-yl-benzyl)-amino]-propyl}-thiophene-2-carboxylic acid

Product 1

HCID 541980265-{3-[(Pyridine-3-sulfonyl)-(4-thiazol-2-yl-benzyl)-amino]-propyl}-thiophene-2-carboxylic acid methyl ester

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound of Step B was prepared from 5-[3-(4-thiazol-2-yl-benzylamino)-propyl]-thiophene-2-carboxylic acid methyl ester of Step A and pyridine-3-sulfonyl chloride hydrochloride, of Preparation 2, following the method described in Example 1, Step B using triethylamine in place of N,N-diisopropylethylamine. MS 514 (M+1).

Sources & evidence

ORD record
ord-c08b89b540de46b0bb1ad596e920f225
Source dataset
uspto-grants-2008_10
Patent number
US07442702B2

Reaction notes

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