Triethylamine → 3-(3-{[(Pyridine-2-sulfonyl)-(4-pyrimidin-5-yl-benzyl)-amino]-methyl}-phenyl)-propionic acid methyl ester

HRID 2117511Notes

Reaction equation

HRID 2117511 reaction equation
[CH3:1][O:2][C:3](=[O:27])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][NH:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[N:25][CH:24]=CN=3)=[CH:17][CH:16]=2)[CH:7]=1.Cl.[N:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[S:35](Cl)(=[O:37])=[O:36].[CH2:39]([N:41](CC)CC)C>>[CH3:1][O:2][C:3](=[O:27])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]([S:35]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][N:29]=2)(=[O:37])=[O:36])[CH2:14][C:15]2[CH:16]=[CH:17][C:18]([C:21]3[CH:39]=[N:41][CH:24]=[N:25][CH:26]=3)=[CH:19][CH:20]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 13791306Pyridine-2-sulfonyl chloride hydrochlorideHCID 541142043-{3-[(4-Pyrazin-2-yl-benzylamino)-methyl]-phenyl}-propionic acid methyl ester

Product 1

HCID 540314093-(3-{[(Pyridine-2-sulfonyl)-(4-pyrimidin-5-yl-benzyl)-amino]-methyl}-phenyl)-propionic acid methyl ester

Procedure

The title compound of Step A was prepared from 3-{3-[(4-pyrazin-2-yl-benzylamino)-methyl]-phenyl}-propionic acid methyl ester, prepared in Step A of Example 11x, and pyridine-2-sulfonyl chloride hydrochloride, of Preparation 47, following the method described in Example 1, Step B using triethylamine in place of N,N-diisopropylethylamine. 1H NMR (400 MHz, CDCl3) δ 8.98 (d, 1H), 8.69 (m, 1H), 8.62 (m, 1H), 8.50 (d, 1H), 7.99 (m, 1H), 7.86 (m, 3H), 7.48 (m, 1H), 7.26 (m, 2H), 7.11 (m, 1H), 7.01 (d, 1H), 6.94 (d, 1H), 6.89 (s, 1H), 4.56 (s, 2H), 4.48 (s, 2H), 3.65 (s, 3H), 2.80 (t, 2H), 2.49 (t, 2H); MS 503 (M+1).

Sources & evidence

ORD record
ord-393d25621850419bb0b21cf7967d67ff
Source dataset
uspto-grants-2008_10
Patent number
US07442702B2

Reaction notes

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