4-(1H-imidazol-1-yl)benzaldehyde → HCID 54139938, compound

HRID 2117516Notes

Reaction equation

HRID 2117516 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH2:11].[N:13]1([C:18]2[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=2)[CH:17]=[CH:16][N:15]=[CH:14]1>CO>[CH3:2][O:3][C:4](=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][CH2:22][C:21]1[CH:20]=[CH:19][C:18]([N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 7365304-(1H-imidazol-1-yl)benzaldehydeHCID 13807349Methyl 7-aminoheptanoate hydrochloride

Product 1

HCID 54139938HCID 54139938, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound of Step A was prepared from 7-amino-heptanoic acid methyl ester hydrochloride, of Preparation 1, and 4-imidazol-1-yl-benzaldehyde, of Preparation 43, using the method described in Example 1, Step A except that the mine was formed in MeOH with a reaction time of 1h. 1H NMR (400 MHz, CDCl3) δ 7.82 (m, 1H), 7.43 (d, 2H), 7.33 (d, 2H), 7.25 (m, 1H), 7.18 (m, 1H), 3.82 (s, 2H), 3.65 (s, 3H), 2.62 (t, 2H), 2.29 (t, 2H), 1.61 (m, 2H), 1.52 (m, 2H), 1.33 (m, 4H).

Sources & evidence

ORD record
ord-9eba4c931a0743cc98915695630a0762
Source dataset
uspto-grants-2008_10
Patent number
US07442702B2

Reaction notes

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