(1,1'-Biphenyl)-4-carboxaldehyde → HCID 53855371, compound

HRID 2117528Notes

Reaction equation

HRID 2117528 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH2:14])[CH:8]=1.[C:16]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:21]=[CH:20][C:19]([CH:22]=O)=[CH:18][CH:17]=1>CO>[CH3:2][O:3][C:4](=[O:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH:14][CH2:22][C:19]2[CH:20]=[CH:21][C:16]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)=[CH:17][CH:18]=2)[CH:8]=1

Participants

4

Reactant 2

HCID 76689(1,1'-Biphenyl)-4-carboxaldehydeHCID 22282736Methyl 3-(3-(aminomethyl)phenyl)propanoate hydrochloride

Product 1

HCID 53855371HCID 53855371, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound of Step A was prepared from 3-(3-aminomethyl-phenyl)-propionic acid methyl ester hydrochloride salt, of Preparation 44, and biphenyl-4-carbaldehyde using the method described in Example 1, Step A except the mine was formed in MeOH at reflux over 3 h. 1H NMR (400 MHz, CDCl3) δ 7.55 (m, 4H), 7.40 (m, 4H), 7.32 (m, 1H), 7.29-7.22 (m, 2H), 7.17 (m, 1H), 7.07 (d, 1H), 3.82 (s, 2H), 3.79 (s, 2H), 3.64 (s, 3H), 2.93 (t, 2H), 2.61 (t, 2H); MS 360 (M+1).

Workup

  1. temperatureat reflux over 3 h

Sources & evidence

ORD record
ord-31190b8096954adcb2e9c6a4b167dd38
Source dataset
uspto-grants-2008_10
Patent number
US07442702B2

Reaction notes

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