Benzenesulfonyl chloride → HCID 57256572, compound

HRID 2117536Notes

Reaction equation

HRID 2117536 reaction equation
[C:1]1([S:7]([N:10]([CH2:21][C:22]2[CH:23]=[C:24]([CH2:28][CH2:29][C:30]([OH:32])=[O:31])[CH:25]=[CH:26][CH:27]=2)[CH2:11][C:12]2[O:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[CH:16]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:33]1(S(Cl)(=O)=O)C=CC=CC=1>C(N(CC)CC)C>[CH3:33][O:31][C:30](=[O:32])[CH2:29][CH2:28][C:24]1[CH:25]=[CH:26][CH:27]=[C:22]([CH2:21][N:10]([S:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)(=[O:9])=[O:8])[CH2:11][C:12]2[O:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[CH:16]=2)[CH:23]=1

Participants

4

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 18376231HCID 18376231, compound

Product 1

HCID 57256572HCID 57256572, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound of Step B was prepared following the method described in Step B of Example 1 from 3-(3-{[(benzofuran-2-ylmethyl)-amino]-methyl}-phenyl)-propionic acid methyl ester of Step A and benzenesulfonyl chloride using triethylamine in place of N,N-diisopropylethylamine. 1H NMR (400 MHz, CDCl3) δ 7.83 (m, 2H), 7.52-7.42 (m, 3H), 7.26-7.09 (m, 8H), 6.39 (d, 1H), 4.46 (s, 2H), 4.39 (s, 2H), 3.68 (s, 3H), 2.88 (t, 2H), 2.57 (t, 2H).

Sources & evidence

ORD record
ord-e349166cce514df8aa25efcdc56df2bb
Source dataset
uspto-grants-2008_10
Patent number
US07442702B2

Reaction notes

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