Hydrochloric Acid → Methyl 7-aminoheptanoate hydrochloride

HRID 2117590Notes

Reaction equation

HRID 2117590 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].[ClH:11].[CH3:12]O>>[ClH:11].[CH3:12][O:9][C:8](=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH2:1]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 135807-Aminoheptanoic acid

Product 1

HCID 13807349Methyl 7-aminoheptanoate hydrochloride

Procedure

A solution of 7-amino-heptanoic acid (3.0 g, 21.0 mmol), in 25 mL MeOH and 2.4 mL concentrated HCl was heated at reflux for 4 hours and was stirred at room temperature for 60 h. The mixture was concentrated in vacuo to afford the title compound (3.3 g). 1H NMR (400 MHz, CD3OD) δ 3.62 (s, 3H), 2.89 (m, 2H), 2.31 (t, 2H), 1.62 (m, 4H), 1.37 (m, 4H).

Workup

  1. temperatureat reflux for 4 hours
  2. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-9e9cee0d43334db0be0931e2d00192cf
Source dataset
uspto-grants-2008_10
Patent number
US07442702B2

Reaction notes

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