N,N-Dimethyl-4-(4-nitrophenyl)-1-piperazinepropanamine → HCID 69067851, compound

HRID 2117626Notes

Reaction equation

HRID 2117626 reaction equation
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=2)[CH2:8][CH2:7]1>CO.[Pd]>[CH3:21][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[CH:14][C:15]([NH2:18])=[CH:16][CH:17]=2)[CH2:8][CH2:7]1

Participants

4

Reactant 1

HCID 69071744N,N-Dimethyl-4-(4-nitrophenyl)-1-piperazinepropanamine

Product 1

HCID 69067851HCID 69067851, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 4-(4-(3-dimethylaminopropyl)piperazino)nitrobenzene (1.5 g) in methanol (50 mL) was hydrogenated at atmospheric pressure over Pd (5% on carbon) (0.3 g; 50% water content) for 4 h. The catalyst was filtered off and the solvent removed under reduced pressure to give the title compound as a brown solid

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-5a1a9c0b42284f04ab202ebd9add427b
Source dataset
uspto-grants-2008_10
Patent number
US07442698B2

Reaction notes

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