反应详情

4-(4-Methylpiperazin-1-yl)carbonylmethylaniline (596 mg, 2.55 mmol) was treated in anhydrous THF (20 mL) under nitrogen with lithium aluminium hydride (291 mg, 2.67 mmol) overnight. The reaction was quenched with water (3×0.29 mL), 15% sodium hydroxide (3×0.29 mL) and again water (3×0.29 mL). The resulting precipitate was removed by filtration. Evaporation of the filtrate afforded the title compound as an orange oil. LC:2.5 min; Rt 0.21(m/z 220, M+H+) 90%, 1HNMR: (400MHz, CDCl3); 2.30 (3H, s), 2.40-2.73 (2H +8H, m), 2.69 (2H, m); 6.62 (2H, d, J 8.31), 6.99 (2H, d, J 8.31).

1. customThe reaction was quenched with water (3×0.29 mL), 15% sodium hydroxide (3×0.29 mL) and again water (3×0.29 mL)
2. customThe resulting precipitate was removed by filtration
3. customEvaporation of the filtrate