Hydroxylamine → HCID 72819808, compound

HRID 2117730Notes

Reaction equation

HRID 2117730 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[O:10])=[CH:4][CH:3]=1.C([O-])(=O)C.[Na+].[NH2:22][OH:23]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:22][OH:23])[C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[O:10])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 787HydroxylamineHCID 517045Sodium AcetateHCID 110421332-(4-Fluorophenyl)-1-(pyridin-4-yl)ethanone

Product 1

HCID 72819808HCID 72819808, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(4-Fluorophenyl)-1-(4-pyridinyl)ethanone (0.1 mol/25.2 g) was suspended in 330 ml of methanol. After addition of sodium acetate (0.44 mol/36.1 g) and hydroxylamine*HCl (0.32 mol/22.0 g), the reaction mixture was heated under reflux with stirring for 1 h. On cooling in an ice bath, the title compound was obtained as a white precipitate. The precipitate was filtered off, washed with H2O and dried over P2O5 under reduced pressure. Yield: 14.3 g (62%)

Workup

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux
  3. temperatureOn cooling in an ice bath

Sources & evidence

ORD record
ord-cfa0554f115d42c9a4bc7d94ecdab9ab
Source dataset
uspto-grants-2008_10
Patent number
US07442713B2

Reaction notes

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