Sodium Hydroxide → HCID 58752328, compound

HRID 2117734Notes

Reaction equation

HRID 2117734 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([S:20][CH2:21][CH2:22][N:23]3C(=O)C4C(=CC=CC=4)C3=O)[N:11]([CH3:19])[C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([S:20][CH2:21][CH2:22][NH2:23])[N:11]([CH3:19])[C:12]=2[C:13]2[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12109522HCID 12109522, compound

Product 1

HCID 58752328HCID 58752328, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

100 ml of HCl 10% are added to 2-{2-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-yl-1H-imidazol-2-ylsulfanyl]ethyl}isoindole-1,3-dione (2 mmol/0.917 g), and the mixture is stirred at room temperature for 6 h. The mixture is then slowly neutralized using 2N NaOH, resulting in the precipitation of 2-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-yl-1H-imidazol-2-ylsulfanyl]ethylamine as a white crystalline powder. The precipitate is filtered off with suction and washed with a little ice-cold water and dried over P2O5.

Sources & evidence

ORD record
ord-3a213d2c42184bdeb1312dd4cbdb1cb7
Source dataset
uspto-grants-2008_10
Patent number
US07442713B2

Reaction notes

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