Sodium Hydroxide → HCID 69312775, compound

Participants

Reaction Steps

100 ml of HCl 10% are added to dimethyl 2-{2-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-yl-1H-imidazol-2-ylsulfanyl]acetylamino}pentanedioate (0.8 mmol/0.400 g) and the mixture is stirred at room temperature for 6 h. The mixture is then slowly neutralized using 2N NaOH, resulting in the precipitation of 1-hydrogen 5-methyl 2-{2-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-yl-1H-imidazol-2-ylsulfanyl]acetylamino}pentanedioate as a yellowish crystalline powder. The precipitate is filtered off with suction and washed with a little ice-cold water and dried over P2O5.

Provenance & Evidence