Sodium Hydroxide → HCID 69312775, compound

HRID 2117737Notes

Reaction equation

HRID 2117737 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([S:20][CH2:21][C:22]([NH:24][CH:25]([CH2:30][CH2:31][C:32]([O:34][CH3:35])=[O:33])[C:26]([O:28]C)=[O:27])=[O:23])[N:11]([CH3:19])[C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([S:20][CH2:21][C:22]([NH:24][CH:25]([CH2:30][CH2:31][C:32]([O:34][CH3:35])=[O:33])[C:26]([OH:28])=[O:27])=[O:23])[N:11]([CH3:19])[C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69309362HCID 69309362, compound

Product 1

HCID 69312775HCID 69312775, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

100 ml of HCl 10% are added to dimethyl 2-{2-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-yl-1H-imidazol-2-ylsulfanyl]acetylamino}pentanedioate (0.8 mmol/0.400 g) and the mixture is stirred at room temperature for 6 h. The mixture is then slowly neutralized using 2N NaOH, resulting in the precipitation of 1-hydrogen 5-methyl 2-{2-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-yl-1H-imidazol-2-ylsulfanyl]acetylamino}pentanedioate as a yellowish crystalline powder. The precipitate is filtered off with suction and washed with a little ice-cold water and dried over P2O5.

Sources & evidence

ORD record
ord-65cb374ab3e442338e1ad0dea08f0e17
Source dataset
uspto-grants-2008_10
Patent number
US07442713B2

Reaction notes

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