Sodium Hydroxide → 2-[5-(2-aminopyridi n-4-yl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-2-ylsulfanyl]-N,N-bis(2-hydroxyethyl)acetamide

Participants

Reaction Steps

50 ml of HCl 10% are added to 2-[5-(2-acetylaminopyridin-4-yl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-2-ylsulfanyl]-N,N-bis(2-hydroxyethyl)acetamide (0.6 mmol/0.293 g), and the mixture is stirred at room temperature for 6 h. The mixture is then slowly neutralized using 2N NaOH, resulting in the precipitation of 2-[5-(2-aminopyridi n-4-yl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-2-ylsulfanyl]-N,N-bis(2-hydroxyethyl)acetamide as a whitish powder. The precipitate is filtered off with suction, washed with a little ice-cold water and dried over P2O5.

Provenance & Evidence