Sodium Hydroxide → 2-[5-(2-aminopyridi n-4-yl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-2-ylsulfanyl]-N,N-bis(2-hydroxyethyl)acetamide

HRID 2117740Notes

Reaction equation

HRID 2117740 reaction equation
C([NH:4][C:5]1[CH:10]=[C:9]([C:11]2[N:15]([CH3:16])[C:14]([S:17][CH2:18][C:19]([N:21]([CH2:25][CH2:26][OH:27])[CH2:22][CH2:23][OH:24])=[O:20])=[N:13][C:12]=2[C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)[CH:8]=[CH:7][N:6]=1)(=O)C.[OH-].[Na+]>Cl>[NH2:4][C:5]1[CH:10]=[C:9]([C:11]2[N:15]([CH3:16])[C:14]([S:17][CH2:18][C:19]([N:21]([CH2:25][CH2:26][OH:27])[CH2:22][CH2:23][OH:24])=[O:20])=[N:13][C:12]=2[C:28]2[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=2)[CH:8]=[CH:7][N:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 587523312-[5-(2-Acetylaminopyridin-4-yl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-2-ylsulfanyl]-N,N-bis(2-hydroxyethyl)acetamide

Product 1

HCID 587523322-[5-(2-aminopyridi n-4-yl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-2-ylsulfanyl]-N,N-bis(2-hydroxyethyl)acetamide

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

50 ml of HCl 10% are added to 2-[5-(2-acetylaminopyridin-4-yl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-2-ylsulfanyl]-N,N-bis(2-hydroxyethyl)acetamide (0.6 mmol/0.293 g), and the mixture is stirred at room temperature for 6 h. The mixture is then slowly neutralized using 2N NaOH, resulting in the precipitation of 2-[5-(2-aminopyridi n-4-yl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-2-ylsulfanyl]-N,N-bis(2-hydroxyethyl)acetamide as a whitish powder. The precipitate is filtered off with suction, washed with a little ice-cold water and dried over P2O5.

Sources & evidence

ORD record
ord-dbbf1d9e227b44ce938bcef7a8501ee1
Source dataset
uspto-grants-2008_10
Patent number
US07442713B2

Reaction notes

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