HCID 69309075, compound → HCID 69310523, compound

HRID 2117764Notes

Reaction equation

HRID 2117764 reaction equation
[CH3:1][C:2]([CH3:27])([CH3:26])[CH:3]=[CH:4][C:5]1[N:6]([CH2:23][CH2:24][CH3:25])[C:7]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:11]=2)=[CH:8][N:9]=1>[Pd].C(O)C>[CH3:1][C:2]([CH3:26])([CH3:27])[CH2:3][CH2:4][C:5]1[N:6]([CH2:23][CH2:24][CH3:25])[C:7]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:11]=2)=[CH:8][N:9]=1

Participants

4

Reactant 1

HCID 69309075HCID 69309075, compound

Product 1

HCID 69310523HCID 69310523, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 10% palladium on charcoal catalyst (100 mg), 4-[2-(3,3-dimethylbut-1-en-1-yl)-1-(propyl)imidazol-5-yl]-2-anilinopyrimidine (Method 114; 230 mg, 0.64 mmol) in ethanol (50 ml) was stirred under an atmosphere of hydrogen for 72 hours. The catalyst was removed by filtration through diatomaceous earth, and the filter pad washed with warm MeOH. The solvent removed by evaporation to give the title compound (200 mg, 86%). M/z 364.

Workup

  1. customThe catalyst was removed by filtration through diatomaceous earth
  2. washthe filter pad washed with warm MeOH
  3. customThe solvent removed by evaporation

Sources & evidence

ORD record
ord-d62946084c5342fe943bd9e24d165968
Source dataset
uspto-grants-2008_10
Patent number
US07442697B2

Reaction notes

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