HCID 178418361, compound → HCID 178511305, compound

HRID 2117800Notes

Reaction equation

HRID 2117800 reaction equation
[N:1]([CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[C:19]3[N:18]=[CH:17][N:16]=[C:14]([OH:15])[C:13]=3[N:12]=[CH:11]2)[C@H:7]([OH:20])[C@@H:6]1[OH:21])=[N+]=[N-].[H][H]>CO>[NH2:1][CH2:4][C@H:5]1[O:9][C@@H:8]([N:10]2[C:19]3[N:18]=[CH:17][N:16]=[C:14]([OH:15])[C:13]=3[N:12]=[CH:11]2)[C@H:7]([OH:20])[C@@H:6]1[OH:21]

Participants

4

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 1785145949-[(2R,3R,4S,5R)-5-(azidomethyl)-3,4-dihydroxyoxolan-2-yl]-3H-purin-6-one

Product 1

HCID 178511305HCID 178511305, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The thus-obtained 5′-azido-5′-deoxyinosine was then dissolved in methanol and reduced with hydrogen for 12 hours using palladium-on-carbon Pd/C (10%, 80 mg) as a catalyst, whereby 5′-amino-5′-deoxyinosine was obtained. Yield 91%.

Sources & evidence

ORD record
ord-7881e23a7ddd4bdfa1f4a0a97aada1a0
Source dataset
uspto-grants-2008_10
Patent number
US07442788B2

Reaction notes

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