反应详情

温度

200 °C

A mixture of 2-hydroxy-6-phenylpyridine (1.0 g, 5.8 mmol), 2-bromo-6-phenylpyridine (1.4 g, 5.8 mmol) and potassium carbonate (807 mg, 5.8 mmol) was stirred at 200° C. for 8 hours. After the reaction mixture was cooled, to which was then added an aqueous 1 mol/L sodium hydroxide solution, the mixture was extracted with dichloromethane, the solvent was distilled off, and the residue was purified by silica gel column chromatography, thereby obtaining 1.3 g of 2,2′-oxybis(6-phenylpyridine) as colorless crystal.

1. temperatureAfter the reaction mixture was cooled, to which
2. extractionthe mixture was extracted with dichloromethane
3. distillationthe solvent was distilled off
4. customthe residue was purified by silica gel column chromatography