Diisopropylamine → Lithium diisopropylamide mono(tetrahydrofuran)

HRID 2117816Notes

Reaction equation

[CH:1]([NH:4][CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2].CCCCCC.C([Li:18])CCC.[O:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>>[O:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1.[CH:1]([N-:4][CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2].[Li+:18]

Participants

Reactant 3

HCID 7912Diisopropylamine

HCID 8028Tetrahydrofuran

HCID 178418244HCID 178418244, compound

Product 1

HCID 10997623Lithium diisopropylamide mono(tetrahydrofuran)

Procedure

A tetrahydrofuran (8 ml) solution of diisopropylamine (1.0 ml, 7.1 mmol) was cooled to 5° C., then n-butyllithium hexane solution (4.1 ml, 1.58 M, 6.5 mmol) was dropwise added thereto while 10 minutes, thus lithium diisopropylamide tetrahydrofuran solution was obtained.

Sources & evidence

ORD record: ord-02b7c89c8ef84bdc934cb875a5c74b90
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07442797B2

Reaction notes

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