Hydrochloric Acid → HCID 178474416, compound

HRID 2117863Notes

Reaction equation

HRID 2117863 reaction equation
[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH:18][CH:19]([NH:28]C(=O)OC(C)(C)C)[NH:20]C(=O)OC(C)(C)C)=[CH:12][CH:11]=2)[N:9]=1)(=[O:3])[CH3:2].[ClH:36]>O1CCOCC1>[ClH:36].[NH2:28][C:19]([NH:18][CH2:17][CH2:16][C:13]1[CH:12]=[CH:11][C:10]([C:8]2[N:9]=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[S:6][CH:7]=2)=[CH:15][CH:14]=1)=[NH:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86595593HCID 86595593, compound

Product 1

HCID 178474416HCID 178474416, compoundYield 43.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Di-tert-butyl {[(2-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}ethyl)amino]methylidene}biscarbamate (268 mg, 79.2%) (170 mg) was dissolved in 4 N hydrogen chloride in 1,4-dioxane (5 mL). The mixture was stirred at room temperature for 2 days, and then evaporated in vacuo. The residue was washed with ethyl ether, dried in vacuo to give N-{4-[4-(2-{[amino(imino)methyl]amino}ethyl)phenyl]-1,3-thiazol-2-yl}acetamide hydrochloride (50 mg, 43.6%).

Workup

  1. customevaporated in vacuo
  2. washThe residue was washed with ethyl ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-0d682b2583894297a8f100ba04a1e883
Source dataset
uspto-grants-2008_10
Patent number
US07442715B2

Reaction notes

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