Tetrahydrofuran → HCID 86595612, compound

HRID 2117948Notes

Reaction equation

HRID 2117948 reaction equation
C(OC[S:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([NH:20][C:21](=[O:23])[CH3:22])[S:18][CH:19]=2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(=O)C.C1COCC1.[OH-].[Na+:30]>CO>[C:21]([NH:20][C:17]1[S:18][CH:19]=[C:15]([C:12]2[CH:11]=[CH:10][C:9]([S:6]([O-:8])=[O:7])=[CH:14][CH:13]=2)[N:16]=1)(=[O:23])[CH3:22].[Na+:30]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 21914948HCID 21914948, compound

Product 1

HCID 86595612HCID 86595612, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

({4-[2-(Acetylamino)-1,3-thiazol-4-yl]phenyl}sulfonyl)methyl acetate (700 mg), THF (8 ml), MeOH (4 ml) and 1N—NaOH (1.98 ml) were combined. The reaction mixture was stirred at r.t. for 1.5 hours, and concentrated in vacuo. The residual solid was washed with ethyl ether to give sodium 4-[2-(acetylamino)-1,3-thiazol-4-yl]phenylsulfinate (731 mg) as a colorless solid.

Workup

  1. concentrationconcentrated in vacuo
  2. washThe residual solid was washed with ethyl ether

Sources & evidence

ORD record
ord-85a216aa2c97467cb5d0065bb446a5a2
Source dataset
uspto-grants-2008_10
Patent number
US07442715B2

Reaction notes

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