HCID 12192473, compound → HCID 178517440, compound

HRID 2117965Notes

Reaction equation

HRID 2117965 reaction equation
[N+:1]([C:4]1[CH:28]=[CH:27][C:7]([C:8]([CH:10]2[C:14](=[O:15])[NH:13][C:12]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[C:11]2[C:22]([O:24]CC)=[O:23])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2]>CO>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8]2[O:24][C:22](=[O:23])[C:11]3[C:10]=2[C:14](=[O:15])[NH:13][C:12]=3[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:27][CH:28]=1)([O-:3])=[O:2]

Participants

3

Reactant 1

HCID 12192473HCID 12192473, compound

Product 1

HCID 178517440HCID 178517440, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
270 °C

Procedure

The p-nitrobenzoylpyrrolinone ester 11 (300 mg, 0.90 mmol) was irradiated with microwave radiation without solvent, heating to 270° C. for 15 minutes. The crude product was then allowed to cool, methanol was added and the solid filtered off and washed with methanol. This gave the furopyrrole 12 as a red solid (230 mg, 87%).

Workup

  1. temperatureto cool
  2. filtrationthe solid filtered off
  3. washwashed with methanol

Sources & evidence

ORD record
ord-4a7d6cde82674d339b117c4f59669fcc
Source dataset
uspto-grants-2008_10
Patent number
US07442804B2

Reaction notes

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