Cyclopropanecarbonyl chloride → HCID 21064024, compound

HRID 2118036Notes

Reaction equation

HRID 2118036 reaction equation
[CH:1]1([C:4](Cl)=[O:5])[CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:33]=[CH:32][C:11]2[N:12]3[C:16]([CH2:17][NH:18][CH2:19][C:10]=2[CH:9]=1)=[N:15][N:14]=[C:13]3[CH:20]1[CH2:25][CH2:24][N:23]([C:26]2[N:31]=[CH:30][CH:29]=[CH:28][N:27]=2)[CH2:22][CH2:21]1>>[Cl:7][C:8]1[CH:33]=[CH:32][C:11]2[N:12]3[C:16]([CH2:17][N:18]([C:4]([CH:1]4[CH2:3][CH2:2]4)=[O:5])[CH2:19][C:10]=2[CH:9]=1)=[N:15][N:14]=[C:13]3[CH:20]1[CH2:25][CH2:24][N:23]([C:26]2[N:27]=[CH:28][CH:29]=[CH:30][N:31]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 21925629HCID 21925629, compound

Product 1

HCID 21064024HCID 21064024, compoundYield 69%

Procedure

The title compound was prepared as an off-white foam from cyclopropanecarbonyl chloride and the amine of example 12, in 69% yield, using the procedure described in example 3.

Sources & evidence

ORD record
ord-4ee5bf57250f4893aae02f961a259dff
Source dataset
uspto-grants-2008_10
Patent number
US07442795B2

Reaction notes

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