HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 1-Methyl-5-nitro-3-phenyl-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | ethyl 1-methyl-5-nitro-3-phenyl-1H-indole-2-carboxylate | HCID 69231753 | — |
| Product | 1-Methyl-5-nitro-3-phenyl-1H-indole-2-carboxylic acid | HCID 21543518 | — |
Reaction Steps
1-Methyl-5-nitro-3-phenyl-1H-indole-2-carboxylic acid was prepared from ethyl 1-methyl-5-nitro-3-phenyl-1H-indole-2-carboxylate by KOH hydrolysis as a yellowish solid: 1H NMR (DMSO-d6) δ 4.08 (s, 3H, 7.48-7.55 (m, 5H, 7.86 (d, J=9.2 Hz, 1H), 8.21 (dd, J=9.2, 2.3 Hz, 1H, 8.30 (d, J=2.3 Hz, 1H; MS (ESI) m/z 295 [M-H]−; HRMS calcd for C16H13N2O4: 297.0873; found (ESI+): 297.0867; Anal. calcd for C16H12N2O4.0.15H2O: C, 63.32; H, 4.25; N, 9.23. Found: C, 63.34; H, 3.87; N, 9.12.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07442805B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-ee1d392bde86411baa709234f5e10e0e |
| Source note | uspto-grants-2008_10 |