Trifluoroacetic acid → HCID 178468183, compound

HRID 2118262Notes

Reaction equation

HRID 2118262 reaction equation
C([O:5][C:6](=[O:31])[CH:7]([O:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([N:16]([CH3:30])[S:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=2)(=[O:19])=[O:18])[CH2:12][CH2:11]1)[CH3:8])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:30][N:16]([S:17]([C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:28])([F:29])[F:27])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[C@H:13]1[CH2:14][CH2:15][C@H:10]([O:9][CH:7]([CH3:8])[C:6]([OH:31])=[O:5])[CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178468184HCID 178468184, compound

Product 1

HCID 178468183HCID 178468183, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 300 mg (0.64 mmol) of from trans-2-{4-[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-cyclohexyloxy}-propionic acid tert-butyl ester in 3 ml of CH2Cl2 was treated wit 0.5 ml (6.7 mmol, 10 eq) of trifluoroacetic acid and stirred at 40° during 3 h. Evaporation of the solvent gave 266 mg (quantitative) of trans-2-{4-[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-cyclohexyloxy}-propionic acid as an off-white solid, MS: 408 (M−H−).

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-29e4cb7848ce4ec78c4ff80b73b20680
Source dataset
uspto-grants-2008_10
Patent number
US07442791B2

Reaction notes

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