HRID2118328

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

结构：CC1(C)OCc2cc([C@@H](O)CNCCCCCCOCCCCc3cccc(S(=O)(=O)C4CCCC4)c3)ccc2O1

HCID69119807

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Oc1ccc([C@@H](O)CNCCCCCCOCCCCc2cccc(S(=O)(=O)C3CCCC3)c2)cc1CO

HCID69203926

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A stirred solution of (1R)-2-[(6-{4-[3-(Cyclopentylsulfonyl)phenyl]butoxy}hexyl)amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol (110 mg) in glacial AcOH (5 ml) and water (0.3 ml) was heated at 85° C. for 40 min. The solution was evaporated to dryness and the residue was purified by Biotage™ column chromatography on silica using DCM-EtOH-ammonia (50:8:1) as eluent. The residue was dissolved in MeOH, treated with glacial AcOH and the solvent was removed to give the title compound (76 mg). LCMS RT=2.6 min ES+ve 548

WORKUP

后处理

customThe solution was evaporated to dryness
customthe residue was purified by Biotage™ column chromatography on silica
dissolutionThe residue was dissolved in MeOH
additiontreated with glacial AcOH
customthe solvent was removed

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-26138c4a703c441788d334680d5d8f3a
来源数据集: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07442839B2
来源说明: uspto-grants-2008_10

反应 SMILES

[CH:1]1([S:6]([C:9]2[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][CH2:27][C@@H:28]([C:30]3[CH:41]=[CH:40][C:33]4[O:34][C:35]([CH3:39])(C)[O:36][CH2:37][C:32]=4[CH:31]=3)[OH:29])[CH:12]=[CH:13][CH:14]=2)(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.CC(O)=[O:44]>O>[C:35]([O:34][C:33]1[CH:40]=[CH:41][C:30]([C@@H:28]([OH:29])[CH2:27][NH:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][O:19][CH2:18][CH2:17][CH2:16][CH2:15][C:11]2[CH:12]=[CH:13][CH:14]=[C:9]([S:6]([CH:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)(=[O:7])=[O:8])[CH:10]=2)=[CH:31][C:32]=1[CH2:37][OH:44])(=[O:36])[CH3:39]